3-(hydroxycarbamyl) methyl-1-methyl pyridinium iodide



United States Patent 0 3-(HYDROXYCARBAMYL)ME'IHYL-1-ME'IHYL PYRIDINIUIVI IODIDE Thomas Samuel Gardner, Rutherford, N. J., assignor to Hoifmann-La Roche Inc., Nutley, N. 1., a corporation of New Jersey No Drawing. Application July 22, 1955, Serial No. 523,924

1 Claim. (Cl. 260-2955) "ice 3-(hydroxycarbamyl)methyl-l-methylpyridinium iodid is useful as a reactivator of cholinesterase after inhibition of phosphorus esters such as tetraethyl pyrophosphate.

Example 2 g. of 3-pyridineacetohydroxamic acid were suspended in ether and an excess of methyl iodide was added. Suflicient methanol to dissolve the suspended material was added and the solution was permitted to stand for18 hours at room temperature. During this period the solution turned red. The solution was refluxed for one-half hour, then concentrated by distillation in vacuo. Ether was added, whereupon a light brown product crystallized. The 3-(hydroxycarbamyl)methyl-l-methylpyridinium iodide was recrystallized from methanol, M. P. l65l66 C.

Calculated for CaHnINzOz: C, 32.7; H, 3.7. Found: C, 32.9; H, 3.8.

I claim:

3 (hydroxycarbamyl)methyl 1 methylpyridinium iodide.

No references cited. 

